Nike co-founder Phil Knight and his wife Penny Knight have pledged to donate $2 billion to Oregon Health & Science University’s Knight Cancer Institute, the university announced Thursday, describing it as a record-breaking gift.

Oregon Health & Science University said the couple’s donation would be the largest single gift to a higher-learning institution in the United States.

Nike founder Phil Knight and his wife, Penny, are giving $2 billion to a cancer institute at University of Oregon that bears their name, the largest ever donation to a US college or academic health institution,