Previous captain Jamie George has been ruled out of Englands first Six Nations; The England squad has been hit by five injuries including Georges after the weekends club matches and new players have been called up;

First-choice scrum-half Alex Mitchell, who missed the autumn Tests with a neck injury, could also miss the game with a knee problem he picked up against Munster on Friday

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.

England vice-captain Jamie George has been ruled out of the Six Nations opener against defending champions Ireland on February 1, the Rugby Football Union announced on Tuesday.

England have suffered significant injury news ahead of the Six Nations with Jamie George set to miss their opening fixture against Ireland. Hooker George, who has been replaced by Maro Itoje as captain,