NBC Sports NFL commentator Michael Holley has major concern for San Francisco 49ers over Christian McCaffrey entering 2025 season.

McCaffrey will not join Brock Purdy and the majority of San Francisco's starters in suiting up for Saturday's preseason game against the Raiders, David Lombardi of SFStandard.com reports.

San Francisco 49ers quarterback Brock Purdy confidently proclaimed star running back Christian McCaffrey is 'back' after a down 2024 NFL season.

San Francisco 49ers running back Christian McCaffrey is eager to make his long-awaited return after an injury-plagued 2024 ...

Discover the top San Francisco 49ers fantasy football sleepers, breakout candidates, and risk-reward stars for the 2025 season, including Ricky Pearsall.

The injury-riddled 49ers do have some players worth watching in Saturday’s preseason visit to the Raiders after possible ...

The 49ers are hoping for a major rebound in the 2025 season after disaster in 2024, and they part company with veteran tight end ...

Strength of schedule is most often discussed after the NFL releases its seasonal slate, as 2025 opponents’ records from the previous season are compiled and ave ...