Brian Branch sat on a chair in the Detroit Lions locker room Monday night, wearing his full uniform, staring straight ahead.

The record for most wins by a wild-card team will be reset as the loser of the Vikings-Lions game Sunday night will hold the new standard.

Quarterback Brock Purdy will not be available to play in the 49ers’ season finale against the Arizona Cardinals on Sunday.

The Deebo Samuel Era with the 49ers may have just come to an abrupt end. Samuel will miss the 49ers' season finale against the Cardinals on Sunday with injuries ...

Never before in NFL history have two teams with at least 14 wins each gotten together for a regular-season matchup. But that ...

Brock Purdy may have cost himself some serious money this season. He wasn't bad, but he wasn't good, either. He was remarkably mediocre.

Oddsmakers project the San Francisco 49ers (6-10) to put up a fight in their attempt to break their three-game losing streak, ...

BOTTOM LINE: Tulane visits Charlotte after Amira Mabry scored 21 points in Tulane's 72-64 loss to the Rice Owls. The 49ers have gone 3-3 in home games. Charlotte is seventh in the AAC at limiting ...

When making his official selection, Samuel quickly said Lamar Jackson and the Ravens would be the Super Bowl 59 champions. "I ...

Preview the Week 18 matchup between the Arizona Cardinals and San Francisco 49ers with predictions, odds, over/under, spread, ...

Arizona State RB Cam Skattebo adds fuel to discussions linking him to San Francisco 49ers draft strategy amid backfield challenges.

At State Farm Stadium on Sunday, James Conner and the Arizona Cardinals meet George Kittle and the San Francisco 49ers in a ...