Steve Borthwick has been forced into a drastic reshuffle of his Six Nations squad after Jamie George was ruled out of the opening two rounds, the former captain among four players to withdraw from the England squad.

England have been struck by an injury crisis less than a fortnight before the Guinness Six Nations with vice-captain Jamie George heading a significant list of withdrawals from Steve Borthwick’s squad.

England have suffered significant injury news ahead of the Six Nations with Jamie George ruled out of their opening fixtures against Ireland and France.Hooker George, who has been replaced by Maro Itoje as captain,

England's rugby squad faces significant challenges as they prepare for the Six Nations opener against Ireland. Key players like Jamie George and Alex Mitchell are sidelined due to injuries. Coach Steve Borthwick is forced to make crucial decisions,

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.

Former England captain Jamie George is now a major injury doubt for the Six Nations after picking up a knock in Saracens’ shock 32-24 defeat to Castres last night. George was named England skipper ahead of last year’s Championship,